Brahmanandam was born in Chaganti Vari Palem village, Sattenapalli in Andhra Pradesh. Prior to films, he was a Telugu lecturer in Attili, a town in West Godavari district of Andhra Pradesh. He entered in tollywood with popular Telugu director and writer, 'Jandhyala', with the movie Aha Na Pellanta in 1987. He has prominently appeared in roles with comic sense. He has also appeared in Tamil movies. Brahmanandam debut movie is 'Tatavataram katha'. Brahmanandam is considered one of the most versatile Indian comic actors, noted particularly for his comic expressions. His elder son, 'Raja Goutham' debuted through 'Pallakilo Pellikooturu', a Telugu film.