Salim Ghouse was born in Chennai. He studied at the Christchurch School and the Presidency College in Chennai. He is also a graduate of Film and Television Institute of India, Pune. He also excels in martial arts. He has acted in films of various Indian languages. He married Anita Salim. He is a martial artist and has obtained his 7th degree Black Belt in Okinawan Goju-ryu Karate. He received the title of Kyoshi-Shihan which means a grandmaster in Reiki. He also researches on the styles of Taichichuan. In 1990, he made portrayed as the villain in the classic Malayalam film, Thazhvaram, directed by Bharathan as the rival to Mohan Lal. He starred alongside Madhuri Dixit and Shahrukh Khan in the 1997 film, Koyla, 1989 Kamal Haasan film, Vetri Vizha, 1993 Mani Ratnam film, Thiruda Thiruda and 2009 film Vettaikaran. He lives in Mumbai, Maharashtra, India.