Jeremiah was born in an Anglo-Indian Roman Catholic family in Arakkonam, Tamil Nadu. Her father is a lawyer at the High Court in Chennai. She has one younger sister who lives and works at Leuven, Belgium as a research assistant. She was raised near Chennai and went to Sacred Heart Matriculation Higher Secondary School and graduated from Women's Christian College. Jeremiah learnt classical piano when she was age of eight. She also organized a company The Show Must Go On (TSMGO Productions) to promote live art and artistes.
Andrea rendering a song in Gautham Menon's Vettaiyaadu Vilaiyaadu, he asked her to play a lead female character in his next venture Pachaikili Muthucharam. She signed for Selvaraghavan's fantasy-adventure film Aayirathil Oruvan. In 2011, she agreed to play a minor supporting role in Venkat Prabhu's multi-starrer Mankatha. In 2013, she made her debut in Malayalam cinema with Rajeev Ravi's romance film Annayum Rasoolum. She played a role in Kamal Haasan's Vishwaroopam and will reprise the role in its sequel, which is to release in 2015. She also performed in Puthiya Thiruppangal, Endrendrum Punnagai and the Malayalam film London Bridge.
She chose to be a professional singer and that acting happened by chance. In 2005, she ventured into playback singing in feature films. She has also received nominations at Filmfare and Vijay Awards for few of them. She considers the song "Maalai Neram" as the most challenging she has sung. Andrea Jeremiah also produces her own music. She composed, wrote and sang a single, titled "Soul of Taramani", as a promo for her Tamil romantic-drama Taramani. She has composed several music themes, songs and albums. Her upcoming films are Idhu Namma Aalu, Taramani, Vishwaroopam 2, Puthiya Thiruppangal, Kadhal 2 Kalyanam, Prakasham Parathunna Penkutty. She diversified in various roles as Actress, Singer, Music Composer, Voice Actress and Dancer.