Anjali did her schooling in Razole and later moved to Chennai, Tamil Nadu where she continued her studies, pursuing a degree in Mathematics. She has two brothers and a sister. After completing her education, she began acting in short films, which paved the way for her entry into the film industry.
In 2002, Anjali was signed on to appear in director Kalanjiyam's Sathamintri Muthamidu and the director also began two other films with Anjali, Valiba Desam and En Kanavu Thaanadi, though those also failed to materialize. Then she did two more films in Telugu, both garnered negative response and performed poorly at the box office. She made her Tamil film début later that year in Kattradhu Thamizh, directed by Ram, which released to strong critical acclaim. She appeared in two films in 2008; Honganasu, her first Kannada project and Aayudham Seivom in Tamil. She next played Kani, a fiery, independent sales girl in a textile showroom in Angadi Theru (2010), who went on to win several accolades directed by Vasanthabalan. She subsequently appeared in two family drama films Rettaisuzhi and Magizhchi, both films failed to succeed at the box office. Meanwhile, she was cast by director A R Murugadoss to perform a lead role in his maiden production Engeyum Eppodhum alongside Jai and she had her only starring role in 2012 in Sundar C's Kalakalappu. In 2013, she starred in the Telugu multi- starrer Seethamma Vakitlo Sirimalle Chettu, a critical and commercial success, with much applause for Anjali from the critics. Her next release was Settai, the Tamil remake of Delhi Belly. She starred in two Telugu films, Gopichand Malineni's Balupu and Masala, the Telugu remake of Bol Bachchan. In 2014, she appeared in a women centric horror film titled Geethanjali for the first time in her carrier. She also enacted in Geethanjali. Her upcoming movies are Sarrainodu, Iraivi , Chitrangada, Peranbu, Karikalan, Madha Gaja Raja, Nataraju Thane Raju (NTR).