Madhavi’s father was a deputy commissioner in commercial tax department, due to which her family moved to various places including Tirupati, Nellore, Guntur,Vijayawada and Hyderabad, before settling in Chennai, Tamil Nadu, where she did her studies. She completed her degree in Biotechnology from Vellore Institute of Technology in 2005.
She began modeling during her college days, first assignment being for Saravana Stores. She did more modelling and went to appear in television advertisements. She was auditioned and selected by noted Telugu director Sekhar Kammula to act in his production, Avakai Biryani.She also did a supporting role in Cheran's Tamil film Pokkisham. She enacted as a leading role in films include Bumper Offer,Om Shanti, Rama Rama Krishna Krishna, Veppam. After Veppam, Madhavi shifted her focus to the Tamil industry as she received more Tamil film offers. Her next Tamil release Kazhugu was a success at the box office. In 2013 she was seen in Kedi Billa Killadi Ranga, Desingu Raja and Varuthapadatha Valibar Sangam all of which were hits. She also did Tamiluku En Ondrai Aluthavum, Oru Kanniyum Moonu Kalavaniyum.Her upcoming films are Jackson Durai, Shoot.