Gopika was born in a Syrian Christian family to Anto Francis and Tessy Anto in Ollur in Thrissur, Kerala. She has one sister, Glini. After completing her 12th standard in St. Raphael's Convent Girls High School, Ollur, she studied sociology at Calicut University. She learnt classical dance from her teacher Kamalher. She was crowned as Miss College during her farewell. The beauty contest Miss Thrissur was a turning point in her life. Though she did not win the title, she stood as the first runner-up in the contest, which gained her a few modeling assignments. She claims that she never wanted to be an actress, and her ambition was to be an airhostess. On 17 July 2008, Gopika married Ajilesh Chacko, a doctor working in Northern Ireland. They have a daughter Amy and a son Aiden. She now lives in Brisbane, Australia.
She made her acting debut in Pranayamanithooval, in which she starred with Jayasurya and Vineeth directed by Thulasi Das. Her second film, 4 the People, was a blockbuster and was dubbed in many Indian languages. Renowned Tamil movie director Cheran signed her up for his filmAutograph, which was another big hit in 2004. She also acted in Kana Kandaen. She has acted in Kannada film Kanasina Loka and the Telugu remake of Azhagi. Her Telugu film Leta Manasulu, directed by Raju Upati, crashed at the box office. She starred in the Malayalam movie Kirtichakra opposite Jiiva. Her previous film with Dileep, Chanthupottu, was a big hit. Veruthe Oru Bharya was a phenomenal hit, and it gained her the Asianet Best Actress award of 2008.