Heera’s father Rajagopal, was a dermatologist in Apollo hospitals, Chennai. Her mother was a nurse in the Indian Army. She graduated in Psychology from Women's Christian College, Chennai. She married Pushkar Madhav, a Businessman, in 2002 and they divorced in 2006. She debuted in Tamil under Satya Jyoti banner with the film Idhayam alongside Murali. This film was a major hit in Tamil as well as Telugu. She debuted in Bollywood with the film Amaanat co-starring Sanjay Dutt. In Malayalam she debuted with Mohanlal in Nirnayam. She appeared in notable films also featuring Kamal Haasan, Mohanlal, Mammootty, Chiranjeevi, Ravichandran, Nagarjuna, Balakrishna, Ajith Kumar, Vineeth, Karthik, Ravi Teja, Ramesh Aravind, and Anil Kapoor. She has appeared in several Tamil, Malayalam, Telugu, Kannada and Hindi films.