Aishwarya Rajesh completed her B.Com degree at Ethiraj College for Women, Chennai. Aishwarya's father Rajesh was an actor who had appeared in 50 films in Telugu. Her grandfather Amarnath, too acted in lead roles, while her aunt Srilakshmi, is a Telugu comedy actor with over 500 films to her credit.
She starts her acting career with Avargalum Ivargalum movie in 2011, after winning the reality dance show Maanada Mayilada, which was followed by minor roles in Sattapadi Kutram and Vilayada Vaa. She appeared in the 2012 cult film, Attakathi and also in the films Aachariyangal and Puthagam. In 2014, she was seen alongside Vijay Sethupathi in two films, Rummy, and Pannaiyarum Padminiyum. Critics praised her performances, especially in Rummy. Later that year, she appeared in a song sequence in R. Parthiepan's Kathai Thiraikathai Vasanam Iyakkam and as the female lead in Thirudan Police. Aishwarya's first release in 2015 was Kaaka Muttai. She also acted in Aarathu Sinam. Her upcoming movies include Hello Naan Pei Pesuren, Manithan, Dharma Durai, Kutrame Thandanai, Idam Porul Eval, Mo, Deepavali Thuppakki, Luthfudeen Basha’s film, Sibiraj’s film.