Jayasudha was born into a Telugu-speaking family. Her aunt is Telugu cinema actress and director Vijaya Nirmala. Jayasudha made her film debut when she was twelve years in the Telugu film Pandanti Kapuram in 1972. Director K. Balachander gave her a small role in the Tamil film Arangetram where she shared space with Kamal Haasan. She acted in a number of films in Telugu and Tamil mostly under Balachander's direction. While her debut role as heroine in the Telugu film Lakshmana Rekha in 1975 got her attention, it was really the title role in Jyothi that made her a big star in Telugu films. She was now called a successor to the great Telugu actress Savitri and performed many strong roles and showed excellent range. Her roles varied from the cute looking teeny bopper who wore minis in Nomu to that of a tortured wife of a sadist husband in K. Balachander's film Idi Katha Kaadu to that of a comedian who discovers that her husband wants to murder her for her wealth in Money. In commercial cinema, she received a huge break when she starred in Adavi Ramudu, which broke box office records. She has acted in 225 Telugu films, and in one year, she had 24 film releases. By 1982, she became such a famous actress that Dasari titled a film that she starred in, Jayasudha, named after her. Her fame also allowed producers to cast her sister Subhashini in supporting roles in some of the films that she starred in, such as Sivaranjani and Meghasandesam. She first married Vadde Ramesh in Vijayawada but it has not worked. Later she married producer Nitin Kapoor, cousin to actor Jeetendra in 1985 and have two children Nihar and Shreayan. She was elected as MLA for Congress from the Secunderabad constituency in 2009 Andhra Pradesh Assembly elections but lost election and was placed 3rd in the 2014 Telangana assembly elections. Her upcoming movie is Brahmotsavam.