Keerthy Suresh was born to Malayali film producer Suresh Kumar and Tamil actress Menaka. She has an elder sister, Revathy Suresh. Until class four, Keerthy did her schooling in Chennai, Tamil Nadu. Then she studied in Kendriya Vidyalaya, Pattom, Thiruvananthapuram before coming back to Chennai to join the Pearl Academy where she completed her degree in fashion design. She also spent time on an exchange program in Scotland for four months, before completing a two-month internship in London.
Keerthy performed as a child actress in a few of her father's productions such as Pilots (2000), Achaneyanenikkishtam (2001) and Kuberan (2002). After 11 years, she made her debut as a lead actress in Priyadarshan's horror comedy Geethaanjali. In 2014, Keerthy had her next release, Ring Master directed by Rafi. The film was a commercial success and being termed a "super hit". Her first film release was A. L. Vijay's romantic comedy Idhu Enna Maayam (2015), though the film did not perform well at the box office. She consequently worked on two films with Sivakarthikeyan in quick succession, Rajini Murugan and Remo, while also playing the lead role in Prabhu Solomon's Mirattu alongside Dhanush. That year, she also signed up her first Telugu film, Aina Ishtam Nuvvu directed by Ramprasad Ragutu. Her upcoming projects are Vijay 60, Kavalai Vendam, Inaa Ishtam Nuvvu, Remo , Pambu Sattai, Mirattu.