Lekha Washington was born to a father of mixed Burmese, Italian and Punjabi ancestry, Kenneth, and a Maharashtrian mother, Geeta. Lekha pursued a degree in Fine Arts at Stella Maris College, Chennai and went on to attend the National Institute of Design taking courses in first, Lifestyle Product Design, and then re-applying to enrol in the Film and Video Communication course. During her time on the course, she made three short films called Spoonerism, Catch 22 and Sunn with locations ranging from Myanmar to Mauritius.
While pursuing her education, she decided to appear in Chetan Shah's experimental English film, Framed, and subsequently received offers to be a music video jockey from SS Music. Lekha was signed on to play the lead role of an orthodox Tamil Brahmin girl alongside Silambarasan in his project Kettavan, however despite completing a schedule the film was shelved and later cancelled. She had earlier made an uncredited appearance in a song from the 1999 romance film Kadhalar Dhinam and also made a guest appearance in director Jeeva's 2007 film Unnale Unnale. In November 2007, Lekha signed on to play a supporting role in R. Kannan's directorial debut Jayamkondaan, Lekha won critical acclaim for her role and subsequently the film went on to become a critical and commercial success. In 2010, Lekha appeared in three films in three regional languages. Her first release was in the multi-starrer Vedam, the film won positive reviews, and the film was commercial success. She then appeared in Pushkar-Gayathri's comedy film, Va, the film receives average reviews. Her final release of the year was the romantic Kannada film,Huduga Hudugi opposite Sameer Dattani, which became a commercial and critical failure, with Lekha receiving mixed reviews for her role. Lekha was signed on to appear in her debut Hindi film, John Owen's Peter Gaya Kaam Se. She has also shot for another Hindi project, Power by Rajkumar Santoshi, though the film has been delayed. She won acclaim for her portrayal of a Tamil Brahmin bride in the romantic comedy Kalyana Samayal Saadham, before portraying a guest role in the action thriller Arima Nambi. Lekha currently owns and runs a product design company called Ajji and currently holds two patents to her name with respect to the products she has created. Lekha has also enjoyed success as a sculptor, Exhibition A, for which she won critical appraisal. Her upcoming film is Jayam Manadi.