Meena was born to Tamil father Durairaj and Malayali mother Raj Mallika from Chirakkal Palace-Kannur Dist. She was enrolled in Vidyodhya schools in Chennai. Later, she was taking up private coaching and completing the 10th standard in vidyodaya schools in Chennai. She went on to get her master's in History from the University of Madras through the Open University system in 2006. She is a trained Bharathanatyam dancer. Meena married Vidyasagar, a Bangalore-based software engineer, on 12 July 2009 at Arya Vysya Samaj Kalyana Mandapam. The couple's have a daughter, Nainika Vidyasagar (born 1 January 2011), who made her acting debut at the age of 5 in Theri (2016) alongside Vijay.
Meena started her career in 1982 as a child artist in the film Nenjangal. She has acted in several films along with Dr. Sivaji Ganesan and Rajinikanth as a child artist. She has appeared in over 45 films as a child artiste. She made her debut in Telugu beside Akkineni Nageswara Rao in Seetharamaiah Gari Manavaralu. She won Nandi Award for Best Actress from the Government of Andhra Pradesh for Seetharamaiah Gari Manavaralu. While she made her debut as a leading lady in Tamil film Oru Pudhiya Kadhai as a leading role. And also starred in Malayalam and Kannada films, her first role in Malayalam that gained attention was in Santhwanam directed by Sibi Malayil. She had hits with the films Nattamai film directed by K. S. Ravikumar. The film became a blockbuster and completed a 175-day run at the box office. The film yejaman was controversial for its climax but went on to become one of the highest grossing films in 1994. The movie was a blockbuster all across Japan. The film was directed by K. S. Ravikumar and produced by K. Balachander, and became the first Tamil film to be dubbed into Japanese, the film grossed a record $1.6 million in Japan in 1998. After marriage, she paired with Ramesh Aravind in the film Hendtheera Darbar, which was a remake of Varavu Ettana Selavu Pathana. After a brief hiatus, Meena returned to Malayalam cinema and will be seen playing the role of wife to Mohanlal in Drishyam, directed by Jeethu Joseph . As per the trade analysts, the film is inching towards an all time blockbuster status. The actress will also be seen in Pramod Payyanur's much awaited movie, Balyakalasakhi alongside Mammootty. Meena will play a leading role in Allari Naresh's upcoming movie Mama Manchu Alludu Kanchu. Meena got also famous in Tamil Television serial sector. She also has been as a playback singer in the film Sena, Kadhal Sadugudu, 16 Vayathinile, and Kadhalism. Meena has rendered voice for Padmapriya for the film Pokkisham.