Meera Jasmine was born in a Syrian Christian family to Joseph and Aleyamma. She has two sisters, Jiby Sara Joseph and Jeny Susan Joseph, who has also acted in films, and two brothers, one of them, George worked as an assistant cinematographer. She completed her schooling in Bala Vihar, Thiruvalla and Marthoma Residential School, Thiruvalla. She had enrolled for a B.Sc degree in Zoology at Assumption College, Changanassery. Meera is married to Anil John Titus on 9 February 2014 who works as an engineer in Dubai.
Meera Jasmine made her debut in the Malayalam film Soothradharan. Her second film was Gramaphone, directed by Kamal. Her third film was Swapnakkoodu, her performance was appreciated and the film was a high commercial success. She rose to fame in Malayalam cinema with the film Kasthooriman, the film was also a success at the box office, running for 100 days. She then paired with Mohanlal in Rasathanthram, the film went on to became a commercial success. She was next featured opposite Mammootty in the critically acclaimed film Ore Kadal. The film was showcased in film festivals and won awards. Her next films Minnaminnikoottam and Rathri Mazha, which released after a long post-production delay, were box office failures. Her Tamil debut was Run, directed by Lingusamy, which became a high success in Tamil Nadu and made her a sought-after actress. She later appeared in SS Stanley in Mercury Pookkal. Her latest Tamil film, Inga Enna Solluthu, got released in December 2011. Meera has acted in 15 Tamil films. She became noted in the Telugu film industry with Run, the dubbed version of the same-titled Tamil film. She was in the Telugu films in 2004 but also entered Kannada cinema in Maurya. Her other Kannada films include Devaru Kotta Thangi and Ijjodu. The latter film was screened at four prestigious domestic film festivals and garnered critical acclaim. Her future films are Sandakozhi 2, Jai Bhavani, Bebbuli.