Reema Sen was born in Kolkata, into a middle class family in 1981. She completed high school from Calcutta, after which her family moved to Mumbai. In Mumbai, she began her modelling career, appearing in a number of advertising campaigns. Reema moved from modelling to acting soon after. Her first film was a low budget film, Chitram, in Telugu, which was a block buster hit. Later she appeared in the Tamil film, Minnale, which was very successful. She tried to enter Bollywood but her first Hindi film Hum Ho Gaye Aap Ke flopped, and she decided to continue working in Tamil cinema. Her appearance in the Tamil film, Rendu, was successful. People found her facial expressions in the film Thimiru endearing and her performance in Vallavan were applauded. Her role in Aayirathil Oruvan was highly praised by viewers and critics. Her upcoming movies include Rajakumari and Thozhan.