Saloni was born into a Sindhi-speaking family. Her father was an assistant commissioner of narcotics. After completing school, she enrolled at the Shreemati Nathibai Damodar Thackersey Women's University (SNDT) near New Marine Lines/Churchgate, Mumbai, and graduated in Psychology. She made her acting debut in the 2003 Hindi film Dil Pardesi Ho Gaya, directed by Sawaan Kumar Tak. She then got to appear in her first Telugu film Dhana 51 and followed it up with Oka Oorillo, both of them ending up as commercial failures. In 2006 she starred in 5 films, performing lead roles in Chukkallo Chandrudu and Kokila in Telugu and Rehguzar and Saawan: The Love Season in Hindi and a special appearance in the film Boss, I Love You. She debuted in the Tamil film industry with a starring role in Madurai Veeran, and in the Kannada, Budhivanta, the latter went on to become a blockbuster. Later in 2009, she appeared as a cameo performance in Mahadeera which was directed by S. S. Rajamouli, also emerging commercially successful. In late 2011, she made a special appearance in the Tamil film Rajapattai, starring Vikram. In 2012, Saloni played a lead female role in Bodyguard alongside Venkatesh and Trisha Krishnan. She next appeared in Adhinayakudu opposite Balakrishna and two Kannada films Lakshmi and Benki Birugali. Her upcoming movies are Jaggi and Rowdy Simha. She appeared in several television advertisements like Vaseline, Lifebuoy, Parachute Oil, Moove, Chic Shampoo, Three Roses tea and Meera soaps.