Sana Khan’s father is from Kannur, Kerala; and her mother, Saeeda, is from Mumbai. Khan completed her high school (12th grade) from Mumbai and did not pursue any further studies as she became involved in modelling at an early age. She worked as model and appearing in more than 30 ad films alongside the likes of Shahrukh Khan and Akshay Kumar. Khan's debut Tamil film was Silambattam. She received praise for her portrayal and won the 2009 ITFA Best New Actress Award in Singapore. In March 2010, her next Tamil film, Thambikku Indha Ooru was released. Later that year, Khan ventured into the Telugu film industry, appearing in Nandamuri Kalyan Ram's Kalyanram Kathi. Khan's next release was the February 2011 bilingual thriller Gaganam/Payanam – shot in Telugu and Tamil, respectively. Khan stepped into Kannada films with Golden Movies’ Kool...Sakkath Hot Maga. Khan will be making her Malayalam film debut with Climax. Khan has also signed up her sixth Tamil film, Thalaivan with Bas. Khan is known for her dance performances, she gave her first such performance on a song in the Tamil film E. In July 2007, she appeared in a music video in the Hindi film Bombay to Goa. In October 2015, she choreographed the Hindi version of Coldplay's Paradise. Khan participated in the Indian celebrity reality TV show Bigg Boss Season 6 as a contestant; she stood third in the show.