Sanusha was born to Santhosh and Usha in Nileshwaram, state of Kerala, India. She has one younger brother Sanoop Santhosh, who is a child artist, known for his acting in Philips and the Monkey Pen. She hails from Nileshwaram, Kasargod District, Kerala; she has studied at Sreepuram School, Kannur. She is doing her graduation in B. com in S.N. College, Kannur. After being popular in TV serials, Sanusha started her film career in 2000 at the age of 5 with the movie Dada Saheb. She has since played in Nalai Namathey, Renigunta, Nandi, "Bangaram" and Eththan.Sanusha won a Special Jury Mention at the 2013 Kerala State Film Awards for Zachariayude Garbhinikal. Her future films are India Today, Iyer in Pakistan.