Uma was born to D. Rajendra Babu, a commercial director in Kannada films, and actress Sumithra, who appeared in regional Indian films. Her younger sister, Nakshatra, made her debut with the film Doo in 2011. Alongside films, she studied B.A, English literature in Indira Gandhi Open University. She eventually married software engineer H. Dushyanth in Bangalore on 2006 and opted against signing any more films thereafter. She made her debut in Veera nadai in 2000 and in the movie vanavil in the same year. Her Telugu debut in Ammo Bomma in 2001. She made her debut in Malayalam film Kuberan in 2002. She had subsequent movies in further years. She made kannada debut in Kallarali Hoovagi in 2006. She also acts in a few serials like Chikamma, the remake of the famous Tamil serial "Chithi" in Kannada and Valli, Tamil Serial.