Mani Sharma was born to violinist Y.N. Sharma. He started his career as a keyboard player in the late 1980s under the guidance of music director Sri Satyam. As a keyboard player, he toured with Padma Bhushan Dr. S.P.Balasubrahmanyam. He used to work with Murali Krish and Chakri Policherla under Maestro Ilaiyaraaja in Chennai. He was also a keyboard player for Raj-Koti and M. M. Keeravani. He was approached by Ram Gopal Varma for the background score of Antham. Varma asked him to compose a single song for his film and he agreed. Then he continued to compose background music for other films like Raathri (Raat), Preminchukundam Raa etc. His first film as a full-time music composer was Super Heroes. Later he got the breakthrough with Chiranjeevi's 1998 film Bavagaru Bagunnara. He is prime music director for top-tier heroes in Tollywood like Chiranjeevi, Mahesh Babu, Pawan Kalyan, Balakrishna and many others. His upcoming soundtracks are Gentlemen, Injimarappa, Rampachodavaram and Monarch.