Anuradha Sriram is married to singer Sriram (whom she met at Wesleyan University). They have two sons named Jayant and Lokesh. She has sung more than 5000 songs in Tamil, Telugu, Malayalam, Kannada and Hindi films. She was born in Chennai to playback singer Renuka Devi and Meenakshi Sundaram Mohan. She did her schooling (I and II standards) in Coimbatore at the St.Francis Matriculation School, and later at the Padma Seshadri Bala Bhavan School. She has a B.A and M.A in music from Madras University and secured the university gold medal in both the courses. She was given a fellowship to do her Master of Arts degree in Ethnomusicology from Wesleyan University, Connecticut.
She specializes in Carnatic music and has sung in over 1000 concerts worldwide. She is keenly interested in folk music. She has featured in a number of 'jugalbandhi' or fusion concerts along with her husband who is a Hindustani maestro.