Mano’s father Rasool, was a musician in the All India Radio, Vijayawada division and his mother Shaheeda, was a popular Stage actress. Inspired heavily by his mother, Mano joined the stage theater and played many historical characters which also involved singing live songs in his own voice. He soon started taking formal training of carnatic classical music under the vocalist Nedunuri Krishnamurthy. Subsequently, he started his film acting career in the late 1970s and acted in about 40 movies as child artist. He featured as a supporting character in films such as Rangoon Rowdy. In 1982, Mano approached the famous composer Chakravarthy seeking a chance for his brother who was upcoming as a Tabla player. However, Chakravarthy insisted that he wanted an assistant like him to sing track songs. Mano, joined his troop and assisted for almost 2 years. In his tenure with Chakravarthy, Mano sang over 2000 tracks for almost all the leading singers. Mano recorded his debut original song in 1984, for the Telugu film Karpoora Deepam. He sang in a 1985 released Kannada film for musician Hamsalekha. Later he made his debut in Tamil films under Maestro Ilaiyaraaja in 1987 for the film Poovizhi Vasalile. In 1987, Mano got a big break by singing popular songs for the film Enga Ooru Pattukkaran. In 1994, he was approached by A. R. Rahman to sing a duet song "Mukkabla" with Swarnalatha for the movie Kadhalan. The song went on to become a huge blockbuster. He dubbed his voice for almost all Rajinikanth starrers in Telugu. He also dubbed his voice for Kamal Hassan in some movies in Telugu. He sang 500 dubbed songs. He has worked as a music composer for the 2008 released Telugu film Sombheri. He also produced two movies dubbed from Telugu to Tamil Madurai Thimiru and Kumaran Rajini Rasigan under the studio name, "Lord Venkateshwara Productions" and "Mano Media Entertainments" respectively. Mano is married to Jameela. They have three children, Shakir and Rafi and a daughter.