Pragathi Guruprasad was born to Guruprasad and Kanaka on 14 September 1997 in Singapore, and she has an elder sister, Saiprithvi. In Singapore, her father taught Carnatic lessons, and since at the age of five, Pragathi had also begun training in carnatic music. Her family subsequently relocated to Fremont, California where she continued learning Carnatic and Hindustani music from both her father at first and then from a teacher, Sangeetha Swaminathan, a disciple of Sudha Raghunathan. She was the runner-up in the third season of the reality-based singing competition Airtel Super Singer Junior. She has sung for music composers such as Anirudh Ravichander and G. V. Prakash Kumar.
She did various Carnatic kacheris(concerts) and competitions across the USA. Now, Pragathi is doing shows across the USA, Europe, and India. Also adding, she sings at many programs at various organizations, such as the Tamil Sangams across North America, and other charity events, too. She also participates in lots of functions held across the globe,such as the Federation of Tamil Sangams of North America Convention of 2013, Kondattam held in Toronto, shows in London, etc. She has recently sung her first single In Europe, titled as Pattampoochi.